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Research Studies on Lithium and Alzheimer’s Disease

A number of studies have looked at the effect of very low doses of lithium as an Alzheimer’s treatment or prevention option.

A 2015 review in the Journal of Alzheimer’s Disease analyzed the data from three randomized placebo-controlled clinical trials of lithium for treating Alzheimer’s patients. The trials found that lithium “significantly decreased cognitive decline as compared to placebo“.
- Research Study: Lithium as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
An October 2017 article in JAMA Psychiatry details a nationwide study in Denmark on the exposure to lithium in drinking water and the incidences of dementia. This was a large study, with 73,000+ dementia patients and 733,000+ people without dementia as the control. The study found a decreased rate of dementia in people with naturally higher levels of lithium in their water (measured since 1986). Association of Lithium in Drinking Water With the Incidence of Dementia
- Research Study: Association of Lithium in Drinking Water With the Incidence of Dementia
- Research Study: Examining the Relationship between Trace Lithium in Drinking Water and the Rising Rates of Age-Adjusted Alzheimer’s Disease Mortality in Texas
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Research Studies on Lithium and Aggressive Crime and Suicide

Using data for 27 Texas counties from 1978-1987, it is shown that the incidence rates of suicide, homicide, and rape are significantly higher in counties whose drinking water supplies contain little or no lithium than in counties with water lithium levels ranging from...

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